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Mississippi County Hospital System

Your Community.
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Delivering exceptional care, advanced technology, and a commitment to the communities we call home.

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Welcome to Mississippi County Hospital System

Mississippi County Hospital System operates Great River Medical Center in Blytheville and SMC Regional Medical Center in Osceola, serving patients throughout Mississippi County and the surrounding region. Great River Medical Center is an acute care hospital providing emergency care, medical and surgical services, women’s health services, diagnostic care, and other hospital-based services. SMC Regional Medical Center operates as a Rural Emergency Hospital, providing 24/7 emergency care, observation services, diagnostic services, and additional outpatient care.

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Great River Medical Center
Great River Medical Center

Great River Medical Center

1520 N Division St, Blytheville, AR 72315

(870) 838-7300

Visiting Hours

8:00 AM - 5:00 PM

After 5:00 PM or on weekends, use the Emergency Room entrance for admission.

Comprehensive Women's Services Emergency Care Services Imaging Services Inpatient Services Outpatient Services Surgical Services Physical Therapy Laboratory Services Infusion Services
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SMC Regional Medical Center
SMC Regional Medical Center

SMC Regional Medical Center

611 W Lee Ave, Osceola, AR 72370

(870) 563-7000

Visiting Hours

8:00 AM - 5:00 PM

After 5:00 PM or on weekends, use the Emergency Room entrance for admission.

24/7 Emergency Care Services Imaging Services Observation Care Physical Therapy Laboratory Services
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Find a Clinic Near You

From Blytheville and Osceola to communities across Northeast Arkansas and Southeast Missouri, MCHS is proud to provide trusted healthcare services close to home.

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Our Services

Comprehensive, state-of-the-art healthcare right where you need it.

Emergency Care

Great River Medical Center & South Mississippi County Regional Medical Center

Women's Health & Obstetrics

Great River Medical Center

Imaging & Radiology

Great River Medical Center & South Mississippi County Regional Medical Center

Physical Therapy

Great River Medical Center & South Mississippi County Regional Medical Center

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Share Your Story

Real experiences from our community members.

"The physical therapy department at MCHS has been incredible. They provided comprehensive occupational therapy that helped me get back on my feet much faster than I expected."

Sarah Jenkins

Physical Therapy Patient

"When my son broke his arm, the ER staff at Great River Medical Center were fast, attentive, and incredibly gentle. I wouldn't trust anyone else with my family's care."

Michael Thompson

Local Resident

"The cardiology team here caught an issue early and essentially saved my life. Their state-of-the-art facility is a blessing for our rural community. Highly recommended!"

David Reyes

Cardiology Patient

"From the front desk to the surgical team, everyone at SMC Regional Medical Center treated me with respect and dignity during my stay. True professionals."

Linda Peterson

Surgery Patient

"Having a world-class imaging center right here in Blytheville saves me hours of driving. Thank you to the wonderful radiology technicians for making me feel comfortable."

James Washington

Radiology Patient

Have Questions? We're Here to Help.

Reach our friendly team by phone or send a message — we'll get back to you as quickly as possible.

(870) 838-7300 Contact Us